Dr Alireza Rouhi Shalmaei Sepsis should be considered as a pathological condition caused by continuous or periodic flows of micro-organisms in the blood from the focus of purulent inflammation, characterized by severe mismatch general disorders and changes in local education centers often purulent inflammation in various organs and tissues. Agents – Staphylococcus aureus, Escherichia coli and Pseudomonas, Proteus, anaerobes, at least – streptococcus, pneumococcus and The pathogenesis of sepsis, etc. is determined by three factors: Microbiological – type, virulence, number and duration of falling into the body of bacteria; method of implementation of infection; amount of destruction tissues, immunological status of the human body. Sepsis can be: Acute (fulminant) with a sharp – with the development of severe clinical picture Cynic within a few days and the lack of remission, subacute – manifested mainly the emergence of metastatic abscesses and less severe common disorders: Chronic – slow the current process with a long, up to several months or even years. periods of remission between the formation of foci of inflammation in various organs and tissues Classification: predsepsis (purulent-resorptive fever), the initial phase of sepsis (toxemia), septicemia (bacteremia without septic metastases); pyosepticemia in monoculture and in association with other coccal flora. the causative agent of suppurative odontogenic inflammatory processes is often self-infection, which is a long time (many years) is a (persistent) in the chronic foci of the maxillofacial region, the presence of anaerobic infections in particular Clostridium; specific pathways of spread through the lymph vessels to regional lymph nodes, causing lymphadenitis, and periadenit phlegmonous adenitis mortality in sepsis ranges from 35% to 69% of cases. Septic process developing in chepyustno-facial region, are divided into: odontogenic; stomatogenny; wound; tonzillogenny; rhinogenous; otogenic. The frequency of odontogenic – 0.87 to 6.6% and 2.2% of the number of hospitalized patients with acute odontogenic infection. For the generalization of infection, according to the presence of a certain number of thoracic spine.